此次剧情设定在60年代，退休在即的琼斯博士的生活被突如其来的海伦娜打破，她希望与他共同寻找历史改变者——命运转盘。此物件曾经是琼斯与纳粹的争夺对象。现在，他不得不再度介入这场争夺，而觊觎此宝物的纳粹残余势力同样重现。

据说外星人在很多年前留下了一个能够控制人心智的神器“水晶头骨”，对它虎视眈眈的不仅仅是印地安那，还有冷酷无情的苏联特工。

Gwen grows up with her romantic mother constantly telling her the story of her courtship and marriage to her father. Nick grows up with an alcoholic father who can't hold a job and whose family, as a result, is forced to move all the time. The two are shaped by this - Gwen a romantic and Nick withdrawn, unsure of himself - as they watch the hugely popular sixties sitcom, "One Big Happy Family." Years later, it is the star of that show, now a child actor gone bad with a history of detox and people always saying, "I thought she was dead," Francesca Lanfield, who connects the two of them, after years of near-misses and almost encounters. Gwen is hired to ghost-write Francesca's autobiography, while Nick, becoming her lover, is the architect who is to design a building on Francesca's property. When Gwen decides to crusade to save Francesca's building, she writes letters to the newspaper which catches Nick's attention - and wins his heart.

二战期间，希特勒在世界各地召集考古学家寻找“失落的约柜”——圣经中引导希伯来人与上帝交流的圣物，希特勒欲借其来护佑纳粹的战争。为了使希特勒的计划破灭，印第安纳琼斯博士奔赴尼泊尔，一边奋力挖掘蛛丝马迹，一边还要与无孔不入的纳粹分子周旋。凭借着过人的智慧和异于常人的胆量及大无畏的勇气，琼斯终于在罗马找到了指示约柜位置的太阳手杖，继而发现了约柜。就在大功告成之际，纳粹军却侵吞了胜利果实，还将琼斯等人留在了蛇穴里！但是无往不胜的琼斯总是有办法死里逃生，并狠狠地还以颜色！

五位船员在茫茫大海中和狂风巨浪搏斗的故事。其中，船长是一个叫比利（乔治·克鲁尼 George Clooney饰）的男人。他刚刚结识了新女友，急需钱来过上新生活。然而附近海域的捕鱼量却一直不景气。除了船长，其余4名船员眼下都需要钱来维持个人的生活。于是，他们决定开往一个相距甚远的海域，就冲着那里丰富的鱼资源。 富贵险中求，尽管比利知道前方可能有风暴，比利还是坚决的往前行使。然而，真实情况比他想象的还要糟糕：风暴异常狂暴，他们正在面临出海生涯以来最为严峻的考验。友情和爱情，在这场风暴中愈磨愈坚。